Schematic illustration of activated and inhibited Wnt/β-catenin pathway. “WNT ON state�? On ligation of Wnts to their receptors composed of frizzled proteins and LRP5/six, the cytoplasmic protein DVL is activated and induces the suppression of GSK3β. Subsequently, stabilized β-catenin translocates in to the nucleus and binds to TCF/LEF transcription factors https://jimij318bgj1.blogunteer.com/profile