The main circulating metabolite of ketamine (norketamine) demonstrated activity at the same receptor with a lot less affinity. Norketamine is about 1/3 as active as ketamine in lowering halothane demands (MAC) of the rat. Administer a benzodiazepine, if clinically indicated, for that prevention of neuropsychological manifestations throughout emergence from anesthesia. https://ketalinic.com/ketamine-r-isomer-s-isomer/