44 Furthermore, anergic cells Generally retain a higher susceptibility to apoptosis Except anti-apoptotic proteins including BCL2 are overexpressed, as is the situation for CLL cells.45 Indeed, most important therapeutic developments occurring in the final 10 years are linked to the inhibition of BCR and BCL2-mediated signaling. mutations and trisomy 12 https://samuele825tch7.blazingblog.com/profile