Mutations in the Autoimmune Regulator (AIRE) gene lead to Autoimmune Polyendocrinopathy Syndrome type 1 (APS1). characterized by the development of multi-organ autoimmune damage. The mechanism by which defects in AIRE result in autoimmunity has been the subject of intense scrutiny. At the cellular level. https://www.markbroyard.com/best-catch-acure-ultra-hydrating-plant-ceramide-daily-facial-lotion-50ml-fashion-great-buy/