There is a release of norepinephrine with the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors while in the dorsal horn to minimize afferent discomfort transmission and deliver analgesia. For that reason, medications like clonidine that target alpha-2 receptors can influence the transmission of pain. : connected to, served https://socialwebconsult.com/story5165236/detailed-notes-on-onolidine